Identification of genes for complex disease using longitudinal phenotypes

BMC Genomic Data

Table 3 Genome Screen Results for AGE = 45

Phenotype		h²	n	covar.^A	1	3	5	7	9	11	13	15	17	19	21	false+
BMI	AGE = 45	76.0	2674	g	0.3	0.1	1.1	0.6	1.2	1.3	20.2	0.5	1.0	0.2	0.1	1.5
	AUC^B	76.2	2674	g	0.5	0.2	1.6	1.0	1.1	1.0	23.0	1.3	1.2	0.3	0.0	1.7
Chol	AGE = 45	59.7	2650	g	1.6	0.4	0.1	1.0	1.2	3.4	0.9	3.2	0.4	0.3	1.7	1.2
	AUC	66.6	2650	a,g	1.3	0.7	0.1	0.5	0.7	4.9	0.6	3.4	0.2	0.3	1.4	1.2
Gluc	AGE = 45	64.6	2412	-	1.0	0.9	22.2	0.3	1.9	0.5	0.0	0.1	0.4	0.1	0.1	1.3
	AUC	62.9	2412	a	1.3	1.0	25.1	0.3	1.7	1.2	0.0	0.0	0.9	0.3	0.0	3.1
HDL	AGE = 45	65.4	1600	b,c,d,g	2.2	0.5	0.1	1.3	8.5	0.4	0.9	0.0	9.8	0.5	0.6	2.4
	AUC	66.1	1600	b,c,d,g	2.9	0.8	0.5	1.1	9.0	0.2	0.5	0.0	8.6	0.7	0.3	2.8
Height	AGE = 45	73.7	2585	g	0.2	1.1	12.3	4.7	0.3	0.2	1.9	0.6	0.3	0.2	0.0	0.7
	AUC	75.0	2585	g	0.4	0.8	13.8	5.1	0.5	0.2	1.3	1.0	0.6	0.1	0.0	0.9
SBP	AGE = 45	74.7	2411	a,b,c	0.5	0.8	2.0	1.5	1.1	0.1	1.2	3.6	0.3	1.2	21.1	2.1
	AUC	71.3	2411	a,b,c	0.7	2.4	2.7	3.0	0.7	0.0	1.4	5.3	0.3	0.8	26.8	1.9
Tg	AGE = 45	53.2	1585	a,b,d,g	6.2	0.2	0.9	0.7	1.7	1.4	0.3	0.3	0.6	0.3	0.5	1.6
	AUC	51.9	1585	a,b,d,g	7.6	0.2	0.7	1.3	2.9	2.5	0.3	0.2	0.6	0.5	0.4	1.1

^ASignificant covariates employed in the linkage analysis (a, average age in study; b, body mass index; c, cigarettes per day; d, drinks, alcohol consumption, g, gender). ^BResults of the longitudinal data with only those individuals included in the cross-sectional design. Only odd chromosomes contain genes; even chromosomes are summarized as highest false positive (false+).

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