An autosome-wide search using longitudinal data for loci linked to type 2 diabetes progression

BMC Genomic Data

Table 3 Comparison of linkage results for subjects in G2 (R4) versus in G3 (R1 and R2)

Ch #	Phenotype Group Rate: Age	Location	Distance (cM)	Most Significant Marker	Most Significant P-value
1	R4G2: 43–47	q25 ~ q32	176 ~ 218	GATA48B01	^A 5.21 × 10 ^-8
	R2G3: 51–55	p31.1 ~ p22.1	114 ~ 137	ATA29D04	0.0074
	G3 – Mean	p31.1 ~ p22.1	114 ~ 140	ATA2E04	0.0074
3	R4G2: 43–47	p26.3 ~ p21.31	6 ~ 71	GATA164B08	1 × 10 ^-11
	G3 – Mean	p14.1 ~ q12.3	91 ~ 119	GATA128C02	0.0049
8	R4G2: 43–47	q23.1 ~ q24.13	119 ~ 135	GATA7G07	2.94 × 10 ^-6
	R1G3: 43–51	q24.13 ~ q24.22	135 ~ 148	GATA21C12	0.0025
	R2G3: 51–55	q24.13 ~ q24.22	135 ~ 148	GATA21C12	^B 1.06 × 10 ^-4
9	R4G2: 43–47	p24.1 ~ p21.3	14 ~ 44	GATA27A11	7.0 × 10 ^-7
11	R4G2: 43–47	p15.5 ~ p15.2	2 ~ 21	GATA23F06	9.9 × 10^-4
		q22.3 ~ q24.3	101 ~ 131	GATA23E06	3.14 × 10 ^-4
	G2 – Mean	q12.1 ~ q13.5	56 ~ 76	GATA90D07	0.0090
	G3 – Mean Glucose	p14.1 ~ q12.3	91 ~ 119	GATA30G01	6.6 × 10 ^-4
18	R4G2: 43–47	p11.31 ~ q22.1	13 ~ 107	GATA26C03	< 10 ^-11
	R1G3: 43–51	p11.31	3 ~ 7	321xc9	0.007
	R2G3: 51–55	q21.2 ~ q21.32	80 ~ 89	ATA7D07	0.0059

^ABold p-values indicate statistically significant evidence for linkage. ^BItalicized p-values are suggestive evidence for linkage by conventional criteria [9]; marker range in the table corresponds to p-values < 0.01.

ISSN: 2730-6844