Figure 6

Biliary cholesterol and sitosterol concentrations. Female F2 rats, on a defined sitosterol diet (see text) had their bile ducts cannulated and bile collected under gravity and analyzed for cholesterol (panel A) or sitosterol (panel B). No differences in the cholesterol content of bile were noted between any of the genotypes. Note that the concentration of cholesterol is approximately 50-fold more than sitosterol. Interestingly, the sitosterol concentration in the F2 HMZ rats was increased significantly by ~ 50% relative to WT and HET rats (panel B).