Genome-wide transcriptome analysis of hypothalamus in rats with inherited stress-induced arterial hypertension

Klimov, Leonid O.; Ershov, Nikita I.; Efimov, Vadim M.; Markel, Arcady L.; Redina, Olga E.

doi:10.1186/s12863-015-0307-8

BMC Genomic Data

Table 4 The top 40 differentially expressed genes making the greatest contribution to the inter-strain differences in hypothalamic function of ISIAH and WAG rats

From: Genome-wide transcriptome analysis of hypothalamus in rats with inherited stress-induced arterial hypertension

Gene symbol	Acc.#	Correlation	log2 (fold_change) ISIAH/WAG	Definition	Function and/or process
Retsat	NM_145084	0.998	1.82	retinol saturase (all trans retinol 13,14 reductase)	oxidoreductase activity [64]
Sc5d	NM_053642	0.997	1.21	sterol-C5-desaturase	cholesterol biosynthetic process via lathosterol [65] fatty acid metabolic process; lathosterol oxidase activity [66]
RGD1359290	NM_001047898	0.996	was detected in ISIAH but not in WAG	Ribosomal_L22 domain containing protein RGD1359290	structural constituent of ribosome
Abcg2 ^a	NM_181381	0.994	1.83	ATP-binding cassette, subfamily G (WHITE), member 2	transmembrane transport [67]
Ephx2 ^a,b	NM_022936	0.993	4.40	epoxide hydrolase 2, cytoplasmic	positive regulation of blood pressure [24]
Fam111a	NM_001109163	0.993	5.12	family with sequence similarity 111, member A	DNA replication [68]
RGD1563482 ^a	NM_001109065	0.990	0.79	similar to hypothetical protein FLJ38663	aminoacyl-tRNA hydrolase activity
Stra6	NM_001029924	0.990	0.70	stimulated by retinoic acid 6	transports retinol across the cell membrane [18]
Aox2	NM_001008522	0.985	1.47	aldehyde oxidase 2	oxidoreductase activity
Fhit	NM_021774	0.983	1.46	fragile histidine triad	nucleotide metabolic process [69]
Tekt4	NM_001013965	0.981	1.00	tektin 4	protein binding [70]
LOC689064	NM_001111269	0.980	3.23	beta-globin	oxygen transporter activity
Grhl3	NM_001106690	0.976	1.37	grainyhead-like 3 (Drosophila)	may stimulate migration of endothelial cells [71]
Acad9	NM_181768	0.975	0.59	acyl-CoA dehydrogenase family, member 9	oxidoreductase activity catalyze the rate-limiting step in the beta-oxidation of fatty acyl-CoA
Tgfb2 ^a	NM_031131	0.975	0.85	transforming growth factor, beta 2	promotes the survival of dopaminergic neurons [37]
Spg7	NM_181388	0.975	0.58	spastic paraplegia 7 homolog (human)	metalloendopeptidase activity [72] nervous system development [73]
Idnk	NM_001037362	0.974	0.91	idnK, gluconokinase homolog (E, coli)	gluconokinase activity
Lyz2	NM_012771	−0.968	−0.68	lysozyme 2	lysozyme activity
Mal ^a	NM_012798	−0.971	−0.72	mal, T-cell differentiation protein	myelination [74]; structural constituent of myelin sheath [75]
Lcat	NM_017024	−0.972	−0.77	lecithin cholesterol acyltransferase	phospholipase A2 activity [76] cholesterol metabolic process [77]
PCOLCE2	NM_001127640	−0.972	−2.12	procollagen C-endopeptidase enhancer 2	collagen binding [78]
RT1-S3	NM_001008886	−0.974	−2.03	RT1 class Ib, locus S3	antigen processing and presentation of peptide antigen via MHC class I
Cst3 ^a,b	NM_012837	−0.976	−0.59	cystatin C	prevents oxidative stress-induced death [44]
Cyp2j10	NM_001134980	−0.977	−0.94	cytochrome P450, family 2, subfamily j, polypeptide 10	EETs biosynthesis [79]
Gstm4	NM_001024304	−0.978	−1.75	glutathione S-transferase mu 4	glutathione binding glutathione metabolic process
Grm2	NM_001105711	−0.979	−1.81	glutamate receptor, metabotropic 2	regulation of synaptic transmission, glutamatergic [80]
Mx2	NM_134350	−0.979	−1.29	myxovirus (influenza virus) resistance 2	innate immune response [81]
Zfp385d	NM_001013992	−0.980	−0.74	zinc finger protein 385D	zinc ion binding
Tnnt1	NM_001277260	−0.981	−4.37	troponin T type 1 (skeletal, slow)	regulation of muscle contraction [82]
Cpz	NM_031766	−0.982	−0.89	carboxypeptidase Z	zinc ion binding metallocarboxypeptidase activity extracellular matrix homeostasis
Pyroxd2	NM_001004261	−0.983	−2.86	pyridine nucleotide-disulphide oxidoreductase domain 2	oxidoreductase activity
Rbp4	NM_013162	−0.985	−1.49	retinol binding protein 4, plasma	retinol transporter activity [83]
Abca8a	NM_001281824	−0.987	−0.65	ATP-binding cassette, subfamily A (ABC1), member 8a	transporter activity lipid transport transmembrane transport
Mpeg1	NM_022617	−0.989	−2.31	macrophage expressed 1
Grifin	NM_057187	−0.989	−4.44	galectin-related inter-fiber protein	carbohydrate binding
Ltbp2 ^b	NM_021586	−0.989	−2.88	latent transforming growth factor beta binding protein 2	decreases fibroblast adhesion to fibronectin [84] negatively regulates coalescence of oxytalan fibers induced by stretching stress [85]
Snx14	NM_001108174	−0.990	−0.85	sorting nexin 14	phosphatidylinositol-3,5-bisphosphate binding [86]
Pnpla1	NM_001191841	−0.993	−2.59	patatin-like phospholipase domain containing 1	lipid catabolic process
RT1-A2	NM_001008829	−0.993	−1.98	RT1 class Ia, locus A2	antigen processing and presentation of peptide antigen via MHC class I
RGD1309362	NM_001024884	−0.995	−2.46	similar to interferon-inducible GTPase

Genes associated with: ^acentral nervous system diseases; ^b-hypertension; ISIAH and WAG – rat strains used in the study

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