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Fig. 1 | BMC Genomic Data

Fig. 1

From: Re-wiring and gene expression changes of AC025034.1 and ATP2B1 play complex roles in early-to-late breast cancer progression

Fig. 1

A comprehensive assessment of breast cancer progression outline. The first step is data cleaning and normalization, the second step is Differential co-expression network (DCRN) reconstruction for four stages, and the third step is the computational approach for scoring and extracting breast cancer-related stage-specific (BCSS) subnetworks for each stage. In the fourth step, the survival analyses were implemented for four BCSS subnetworks, and a risk model fitted to data. In step five, the stage-related genes were detected; in step six, the topological changes, called re-wiring, among prognostic genes were assessed across stages. In step seven, the core biological pathways for stage-specific subnetworks were detected; in step eight, the breast cancer-specific prognostic genes were detected, and finally in step nine, the computational validation were implemented

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BMC Genomic Data

ISSN: 2730-6844

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