Prediction of the most deleterious non-synonymous SNPs in the human IL1B gene: evidence from bioinformatics analyses

Table 1 The five most deleterious nsSNPs were investigated by SIFT, PolyPhen-2, and PROVEN servers

ID of SNPs	SUB	SIFT		PolyPhen-2 HumDiv¹		PolyPhen-2 HumVar²		PROVEN
ID of SNPs	SUB	Pred	TI	Pred	Sc	Pred	Sc	Pred^*	Sc
rs1449638481	S53Y	deleterious	0	damaged	1	damaged	0.99	deleterious	-4.235
rs1041942016	E100K	deleterious	0	damaged	1	damaged	1	deleterious	-3.211
rs1478935996	D128Y	deleterious	0	damaged	1	damaged	0.992	deleterious	-8.314
rs1199067235	T240I	deleterious	0	damaged	1	damaged	1	deleterious	-5.518
rs1681958816	F228S	deleterious	0	damaged	1	damaged	0.997	deleterious	-4.656

SUB; amino acid substitutions, Pred; prediction, Sc; score, ^*cutoff= -2.5
¹HumDiv: Mendelian disease variants vs. divergence from close mammalian homologs of human proteins ( > = 95% sequence identity)
²HumVar: all human variants associated with some disease (except cancer mutations)

ISSN: 2730-6844