Fig. 4

The procedure of constructing a ceRNA network specific to a tumor sample. A A reference ceRNA network is first constructed by computing partial correlations between lncRNAs and mRNAs mediated by miRNAs in N normal samples. B A perturbed ceRNA network is obtained by adding a tumor sample of the patient to the N normal samples. C A ceRNA network specific to the tumor sample is obtained by subtracting the reference network from the perturbed network