Fig. 5

The process of performing the Z-test for lncRNA-miRNA-mRNA triplets. A Compute partial correlations \(\rho\) between lncRNAs and mRNAs mediated by miRNAs after adding each tumor sample to normal samples, and select those partial correlations whose absolute values \(>0.7\) and p-value \(< 0.05\). B For each tumor sample, compute the differential partial correlation \(\Delta \rho\) of the lncRNA-miRNA-mRNA triplets from the reference samples. C Select the lncRNA-miRNA-mRNA triplets with the mean \(\Delta \rho \ne 0\)