Table 2 Key functions of the protein products of 16 hub genes of PMOP according to GeneCards, NCBI-gene, UniProt, Enrichr GO molecular function and literature mining
Gene symbol | Gene name | Functions of protein product as per NCBI-gene and UniProt |
|---|---|---|
ESR1 | Estrogen receptor 1 (alpha) | Transcription factor, nuclear hormone receptor, modulate angiogenesis in adipose tissue |
CTNNB1 | Catenin beta 1 | Intracellular signal transducer, coactivator for transcription factors of the TCF/LEF family |
GAPDH | Glyceraldehyde-3-phosphate dehydrogenase | Enzyme, Component of OCA-S transcriptional coactivator complex |
IGF1 | Insulin like growth factor 1 | Hormone activity, growth factor activity |
IL1B | Interleukin 1 Beta | Pro-inflammatory cytokine, role in angiogenesis |
IL6 | Interleukin 6 | Cytokine, role in angiogenesis |
MAPK3 | Mitogen-activated protein kinase 3 | Kinase, phosphorylation of transcription factors |
SPP1 | Secreted phosphoprotein 1 | Osteopontin, cytokine, bone protein, extracellular matrix binding viz. hydroxyapatite binding |
TNF | Tumor necrosis factor | An adipokine and a cytokine, role in angiogenesis |
VEGFA | Vascular Endothelial Growth Factor A | Heparin-binding protein, cytokine, role in angiogenesis |
RUNX2 | RUNX Family Transcription Factor 2 | Transcription factor, osteoblastic differentiation, role in angiogenesis and bone vascularization |
TLR4 | Toll Like Receptor 4 | Single transmembrane cell-surface receptors, mediate cytokine secretion and inflammatory response, role in angiogenesis |
BGLAP | Bone Gamma-Carboxyglutamate Protein | Osteocalcin, bone protein, calcium ion binding, hydroxyapatite binding, role in angiogenesis |
BMP2 | Bone Morphogenetic Protein 2 | Secreted ligand of the TGF-beta receptors, cytokine, role in angiogenesis |
HIF1A | Hypoxia Inducible Factor 1 Subunit Alpha | Transcription factor, role in angiogenesis |
SOX9 | SRY-Box Transcription Factor 9 | Transcription factor |