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Table 5 Mean RNA expression (median count/base) of PMS2 exons in Lynch syndrome-related tissues

From: In silico splicing analysis of the PMS2 gene: exploring alternative molecular mechanisms in PMS2-associated Lynch syndrome

Tissue type

Overexpressed exons

Underexpressed exons

Mean (CI 95%)

Bladder

11, 13, 14

1, 2, 15

0.1937

(0.1502–0.2372)

Brain—cortex

11, 13, 14

1, 2, 15

0.2263

(0.1767–0.2760)

Breast—mammary tissue

11, 13, 14

1, 2, 15

0.1883

(0.1536–0.2230)

Colon—transverse

11, 13, 14

1, 2, 15

0.1392

(0.1114–0.1671)

Colon—sigmoid

11, 13, 14

1, 2, 15

0.1516

(0.1195–0.1837)

Kidney—medulla

10, 11, 13, 14

1, 2, 3, 5

0.1818

(0.1309–0.2327)

Ovary

10, 11, 13, 14

1, 2, 15

0.1728

(0.1371–0.2085)

Pancreas

11, 13, 14

1, 2, 15

0.0618

(0.0501–0.0735)

Prostate

11, 13, 14

1, 2, 4

0.1585

(0.1163–0.2007)

Skin—sun exposed

10, 11, 13, 14

1, 2, 15

0.2941

(0.2360–0.3522)

Stomach

11, 13, 14

1, 2, 15

0.10568

(0.0842–0.1270)

Uterus

11, 13, 14

1, 2, 15

0.1714

(0.1363–0.2065)

Whole blood

1, 11, 13, 14

2, 3, 4, 5, 7

0.0525

(0.0404–0.0646)

  1. Overexpressed exons denote exons with mean expression above the 95% CI. Underexpressed exons denote exons with mean expression below the 95% CI