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Fig. 2 | BMC Genomic Data

Fig. 2

From: The amniote-conserved DNA-binding domain of CGGBP1 restricts cytosine methylation of transcription factor binding sites in proximal promoters to regulate gene expression

Fig. 2

cytosine methylation restriction at TFBSs is an evolutionary property of CGGBP1: (A) JASPAR motifs with low GC content occur similarly in F-len and N-term MeDIP data while most of the motifs with higher GC contents are marginally less abundant in the N-term MeDIP. (B) JASPAR motifs, especially the low GC-content ones, show a higher abundance in C-term MeDIP as compared to F-len. (C and D) Phylogenetic analysis of N-term and C-term show that the C-term (D) is more divergent in vertebrates than the N-term (C). The horizontal axis projects an approximately 1.5x larger distance for all common ancestor nodes. The trees are rooted at “Coelacanth” and representative species for which annotated CGGBPs are available (none available for amphibia) have been used in the analysis. (E-H) The evolutionary conservation status of TFBSs affects their cytosine methylation upon expression of C-term. Of the motifs conserved in euteleostomi (E), tetrapods (F), amniotes (G) or boreoeutheria (H), the highest association of GC-poor motifs with cytosine methylation in C-term is observed for those conserved in amniotes. The correlation coefficients, n counts and p values are marked in top left insets in A, B, and E-H

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BMC Genomic Data

ISSN: 2730-6844

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