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Fig. 3 | BMC Genomic Data

Fig. 3

From: The amniote-conserved DNA-binding domain of CGGBP1 restricts cytosine methylation of transcription factor binding sites in proximal promoters to regulate gene expression

Fig. 3

Truncated forms of CGGBP1 target genes with GC-poor promoters: (A) An unsupervised clustering of expression values from three independent replicate experiments for genes significantly differentially expressed between N-term, C-term and F-len classifies the three samples as expected. Although there are variations between the replicates, the arbitrary expression values show a general repression of expression by C-term and a derepression in N-term as compared to F-len. (B) 3309 genes are commonly upregulated by N-term when compared to FL (N/F) and C-term (N/C); 921 genes are commonly downregulated by C-term when compared to FL (C/F) and N-term (C/N); When these 3309 and 921 genes are compared, a considerably large number of 816 genes are commonly upregulated by N-term (N/F&C) and downregulated by C-term (C/F&N). (C) The C-repressed genes have a GC-poor promoter profile as compared to the reporters assayed on the microarrays. (D) GC-rich motif abundance in C-repressed promoters (red) is lower than expected (blue). However, even if the C-repressed promoters are GC-poor, the most abundant motifs in them are GC-rich

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BMC Genomic Data

ISSN: 2730-6844

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