Pharmacogenomic insights into tuberculosis treatment shows the NAT2 genetic variants linked to hepatotoxicity risk: a systematic review and meta-analysis

Mahajan, Rashmi; Tyagi, Anuj Kumar

doi:10.1186/s12863-024-01286-y

Table 1 Table describing the characteristics and data obtained from 24 studies

From: Pharmacogenomic insights into tuberculosis treatment shows the NAT2 genetic variants linked to hepatotoxicity risk: a systematic review and meta-analysis

Sr. No	Study	Year	Ethnicity	Hepatotoxicity Criteria	Regimen	INH Dosage (mg)	Genotyping method	Median Age	BMI	Total Population	ATDH	SA	SA-ATDH
1	Huang, et al	2002	East Asian	ALT > 2 × ULN	INH, RMP, PZA, EMB	300	RFLP	68.5	Normal	224	33	53	14
2	Vuilleumier, et al	2006	Mixed	ALT > 4 × ULN	INH alone	300	q-PCR	31	n/a	89	8	35	3
3	Cho, et al	2007	East Asian	ALT > 2 × ULN	INH, RMP, PZA, EMB	300	Sequencing	48.95	Normal	132	18	19	7
4	Possuelo, et al	2008	Mixed	ALT > 2 × ULN	INH, RMP, PZA	n/a	Sequencing	36.5	n/a	254	14	69	9
5	Yamada, et al	2009	Mixed	ALT > 2 × ULN	INH alone	300	Sequencing	40.8	Normal	170	23	78	14
6	Bose, et al	2011	South Asian	ALT > 2 × ULN	INH, RMP, PZA, EMB	400	RFLP	37	Normal	218	41	108	29
7	Teixeira, et al	2011	South American	ALT > 3 × ULN	INH, RMP, PZA, EMB	400	Sequencing	45.28	n/a	149	26	82	18
8	Leiro-Fernandez, et al	2011	Caucasian	ALT > 3 × ULN	INH, RMP, PZA	300	RFLP	32.25	Normal	117	50	80	36
9	Sotsuka, et al	2011	East Asian	ALT > 2 × ULN	INH, RMP, PZA	300	RFLP	52.1	Normal	144	66	13	8
10	Mahmoud, et al	2012	Middle East	ALT > 2 × ULN	INH, RMP	n/a	RFLP	42	n/a	66	14	33	11
11	Lv, et al	2012	East Asian	ALT > 2 × ULN	INH, RMP, PZA, EMB	600	RFLP	42	Normal	445	89	92	18
12	Rana, et al	2012	South Asian	ALT > 2 × ULN	INH, RMP, PZA, EMB	300	RFLP	44.5	Normal	251	50	49	19
13	Gupta, et al	2013	South Asian	ALT > 2 × ULN	INH, RMP, PZA, EMB	300	RFLP	37.5	Normal	215	50	91	28
14	Ho, et al	2013	East Asian	ALT > 3 × ULN	INH, RMP, PZA, EMB	300	Mass Array	57	Normal	348	59	79	28
15	Santos, et al	2013	South American	ALT > 3 × ULN	INH, RMP, PZA	n/a	Sequencing	44.9	n/a	270	18	86	11
16	Ng, et al	2014	Mixed	ALT > 3 × ULN	INH, RMP, PZA, EMB	300	Sequencing	48.3	n/a	136	26	79	22
17	Singla, et al	2014	South Asian	ALT > 2 × ULN	n/a	n/a	RFLP	32.66	n/a	408	17	228	15
18	Xiang, et al	2014	East Asian	ALT > 2 × ULN	INH, RMP, PZA, EMB	600	LDR	n/a	n/a	1685	309	529	107
19	Mushiroda, et al	2016	East Asian	ALT > 3 × ULN	INH, RMP, PZA, EMB	n/a	Sequencing	n/a	n/a	366	73	27	13
20	Ben, et al	2017	Middle East	ALT > 2 × ULN	INH, RMP, PZA, EMB	300	RFLP	36	n/a	71	11	42	10
21	Araujo, et al	2020	South American	ALT > 3 × ULN	INH, RMP, PZA	n/a	Sequencing	n/a	Normal	173	53	11	5
22	Cavaco, et al	2022	Mixed	ALT > 2 × ULN	INH, RMP, PZA, EMB	n/a	Sequencing	49.6	n/a	233	103	126	68
23	Jaramillo, et al	2022	South American	ALT > 3 × ULN	INH, RMP, PZA, EMB	n/a	Sequencing	24.25	Normal	377	16	179	9
24	Thomas, et al	2024	South Asian	ALT > 3 × ULN	INH, RMP, PZA, EMB	n/a	q-PCR	47	Normal	130	17	40	9
Total										6671	1184	2228	511

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