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Table 2 Comprises of the data on specific NAT2 slow variant which includes the pooled OR, 95% Cl and p values

From: Pharmacogenomic insights into tuberculosis treatment shows the NAT2 genetic variants linked to hepatotoxicity risk: a systematic review and meta-analysis

Study

NAT2*5/5

Nat2*5/6

NAT2*5/7

Nat2*6/6

NAT2*6/7

NAT2*7/7

Y

N

Y

N

Y

N

Y

N

Y

N

Y

N

Huang, et al

0

1

0

6

0

2

6

10

7

12

1

8

Vuilleumier, et al

3

5

2

9

2

1

4

8

0

1

-

-

Cho, et al

-

-

-

-

0

1

3

2

4

7

0

2

Possuelo, et al

2

31

2

8

1

2

4

16

-

-

0

3

Bose, et al

2

8

7

42

8

12

1

3

8

9

2

3

Teixeira, et al

6

24

5

16

2

5

3

12

0

3

-

-

Leiro-Fernandez, et al

8

8

14

24

7

8

4

3

3

1

0

0

Mahmoud, et al

6

10

3

9

0

1

2

2

-

-

-

-

Lv, et al

0

0

3

8

2

2

7

27

5

29

1

8

Rana, et al

0

3

5

11

8

6

0

2

6

3

0

5

Gupta, et al

8

13

13

27

-

-

7

23

-

-

-

-

Ho, et al

0

4

4

14

4

4

15

31

14

50

3

15

Santos, et al

9

64

0

4

2

4

0

2

0

1

-

-

Xiang, et al

9

62

44

113

13

51

26

111

14

67

1

18

Mushiroda, et al

0

2

1

1

1

0

6

4

4

5

1

2

Ben, et al

2

8

6

15

0

3

2

4

0

2

-

-

Araujo, et al

-

-

-

-

-

-

5

6

-

-

-

-

Jaramillo, et al

7

101

1

13

-

-

-

-

1

53

-

-

Total

62

344

110

320

50

102

95

266

66

243

9

64

Pooled OR

1.2954

1.5967

2.32

1.691

1.5883

0.7604

95% Cl

0.9186—1.8267

1.1976—2.1289

1.6112—3.3405

1.2725—2.2472

0.9813—2.5709

0.4072—1.4201

P (value)

0.1399

0.0014*

 < 0.0001*

0.0003*

0.0597

0.3902

  1. Y = cases with the hepatotoxicity
  2. N = absence of hepatotoxicity
  3. * p value < 0.005, statistically significant