Correlation of METTL4 genetic variants and severe pneumonia pediatric patients in Southern China

BMC Genomic Data

Table 2 Association between METTL4 polymorphisms and the risk of severe pneumonia

CHR	BP	dbSNP	Major allele	Minor allele	HWE	Minor Allele Frequency in Cases	Minor Allele Frequency in Controls	Consequences of the variants	OR (95% CI)	p-value
18	2559434	rs9989554	T	C	0.98	0.30	0.27	Intronic	1.21 (1.09–1.34)	0.00025
18	2554836	rs16943442	A	G	0.23	0.16	0.14	Synonymous	1.22 (1.09–1.34)	0.0026
18	2575199	rs80010836	A	C	0.18	0.16	0.14	Upstream, intronic	1.19 (1.05–1.35)	0.0077
18	2560519	rs2138848	A	C	0.92	0.34	0.32	Intronic	1.13 (1.02–1.24)	0.016
18	2557926	rs9948895	C	G	0.69	0.36	0.35	Intronic	1.08 (0.98–1.20)	0.096
18	2537639	rs17534687	G	A	0.79	0.14	0.13	UTR3	1.15 (1.00–1.31)	0.040
18	2561851	rs12457106	T	A	0.39	0.08	0.09	Intronic	0.86 (0.72–1.02)	0.091
18	2542078	rs72857010	G	C	0.36	0.06	0.05	Intronic	1.11 (0.91–1.36)	0.29
18	2551772	rs66873847	G	A	0.45	0.10	0.10	Intronic	1.06 (0.91–1.23)	0.46
18	2548845	rs2644175	A	G	0.44	0.18	0.18	Intronic	1.04 (0.92–1.17)	0.52
18	2538788	rs11663148	C	T	0.09	0.21	0.21	UTR3	0.98 (0.88–1.10)	0.78

Abbreviations: CHR chromosome, BP base pair (where the SNP is located), SNP single-nucleotide polymorphism, HWE Hardy–Weinberg equilibrium, OR odds ratio, CI Confidence interval
P-values were adjusted by gender and age. The nominal p-values were showed. Calculation of the OR was also based on the risk allele of each SNP

ISSN: 2730-6844