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Table 4 eQTL analysis of potential regulatory SNPs in METTL4 among different tissue

From: Correlation of METTL4 genetic variants and severe pneumonia pediatric patients in Southern China

SNP

Tissue

Effect Size

p-value

rs9989554

Whole Blood

0.13

1.85E-07

 

Adipose - Visceral (Omentum)

0.15

1.49E-06

 

Adipose - Subcutaneous

0.15

9.47E-06

rs16943442

Adipose - Visceral (Omentum)

-0.33

1.38E-08

 

Adipose - Subcutaneous

-0.41

3.77E-09

rs9948895

Cells - Cultured fibroblasts

0.18

5.08E-11

 

Adrenal Gland

0.32

5.81E-07

 

Heart - Left Ventricle

0.25

2.86E-06

 

Brain - Cerebellar Hemisphere

0.28

2.15E-05

 

Esophagus - Gastroesophageal Junction

0.19

1.66E-05

 

Muscle - Skeletal

0.24

4.30E-13

 

Esophagus - Muscularis

0.26

6.82E-10

 

Artery - Aorta

0.22

1.61E-07

 

Brain - Amygdala

0.39

1.21E-05

 

Skin - Sun Exposed (Lower leg)

0.12

7.69E-05

rs2138848

Cells - Cultured fibroblasts

-0.19

1.42E-12

 

Thyroid

-0.13

3.40E-05

 

Testis

-0.22

3.11E-06

 

Adrenal Gland

-0.37

8.96E-09

 

Brain - Frontal Cortex (BA9)

-0.31

1.48E-05

 

Heart - Left Ventricle

-0.24

3.64E-06

 

Brain - Cerebellar Hemisphere

-0.30

5.00E-06

 

Esophagus - Gastroesophageal Junction

-0.22

1.45E-06

 

Muscle - Skeletal

-0.26

2.07E-14

 

Esophagus - Muscularis

-0.28

3.65E-11

 

Artery - Aorta

-0.22

2.41E-07

 

Skin - Not Sun Exposed (Suprapubic)

-0.13

6.61E-05

 

Artery - Tibial

-0.14

6.08E-05

 

Brain - Amygdala

-0.44

1.42E-06

 

Skin - Sun Exposed (Lower leg)

-0.13

8.12E-06

  1. Functional relevance of SNP on gene expression in GTEx database
  2. eQTL expression quantitative trait loci; Effect size, the degree to which an SNP influences the expression of genes in a particular tissue