Fig. 4

RMSD analysis of wild-type CTNS and its variants. The Cα-backbone RMSD of the CTNS protein over time is shown. The y-axis represents the RMSD in nanometers (nm), and the x-axis represents the time in nanoseconds (ns). A WT (black) and G296S (light blue). B WT (black) and G308R (pastel blue). C WT (black) and G308 V (soft orange). D WT (black) and D305G (pale green). E WT (black) and K280 T (soft pink). F WT (black) and G309 V (pastel violet). G WT (black) and F142S (coral red)