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Table 3 Stability predictions for deleterious NsSNPs via I-Mutant 2.0, MUPro, DynaMut2, mCSM, SDM, and DUET

From: Computational prediction of deleterious nonsynonymous SNPs in the CTNS gene: implications for cystinosis

ID of SNPs

SUB

I-Mutant2.0 DDG (Pred)

Mupro

DDG (Pred)

DynaMut2

DDG (Pred)

mCSM Score(Pred)

SDM Score(Pred)

DUET Score (Pred)

rs1413852868

A137D

0.29 (IS)

−0.72 (DS)

−1.47 (DS)

−1.94 (DS)

−2.53 (DS)

−2.18 (DS)

rs1436441738

S141 F

0.57 (IS)

−0.45 (DS)

−0.66 (DS)

−0.79 (DS)

2.40 (IS)

−0.01 (DS)

rs764288123

F142S

−2.50 (DS)

−1.73 (DS)

−2.62 (DS)

−2.81 (DS)

−2.23 (DS)

−2.89 (DS)

rs1555563010

R151G

−2.23 (DS)

−2.00 (DS)

−0.78 (DS)

−0.61 (DS)

−0.85 (DS)

−0.74 (DS)

rs371533565

D161H

−1.74 (DS)

−1.89 (DS)

−1.07 (DS)

−0.89 (DS)

0.48 (IS)

−0.62 (DS)

rs2150925336

S270 F

−0.32 (DS)

−0.21 (DS)

−0.91 (DS)

−1.15 (DS)

0.84 (IS)

−0.78 (DS)

rs2150925451

K280 T

−1.37 (DS)

−0.51 (DS)

−0.94 (DS)

−1.34 (DS)

−1.12 (DS)

−1.40 (DS)

rs2150925451

K280R

−0.50 (DS)

−0.14 (DS)

−0.29 (DS)

−0.71 (DS)

0.39 (IS)

−0.38 (DS)

rs746469285

P283L

−1.47 (DS)

−0.21 (DS)

−0.54 (DS)

−0.47 (DS)

1.57 (IS)

0.17 (IS)

rs1238793405

Q284H

−1.57 (DS)

−0.37 (DS)

−0.72 (DS)

−0.78 (DS)

0.61 (IS)

−1.08 (DS)

rs759363199

S293G

−1.49 (DS)

−0.96 (DS)

−0.50 (DS)

−1.10 (DS)

0.72 (IS)

−0.72 (DS)

rs755702977

G296S

−1.57 (DS)

−1.02 (DS)

−0.05 (DS)

−0.64 (DS)

−4.15 (DS)

−1.06 (DS)

rs1332086669

S298G

−1.92 (DS)

−1.17 (DS)

−0.22 (DS)

−0.58 (DS)

0.72 (IS)

−0.18 (DS)

rs1263951539

D305G

−1.76 (DS)

−1.87 (DS)

−0.75 (DS)

−1.42 (DS)

−0.46 (DS)

−1.41 (DS)

rs746307931

G308R

−1.50 (DS)

−0.27 (DS)

−0.70 (DS)

−1.13 (DS)

−1.89 (DS)

−1.11 (DS)

rs908965524

G308 V

−1.05 (DS)

0.01 (IS)

−0.91 (DS)

−0.40 (DS)

−0.14 (DS)

−0.11 (DS)

rs373903147

G309 V

−0.43 (DS)

−0.42 (DS)

−0.96 (DS)

−0.32 (DS)

−0.14 (DS)

−0.03 (DS)

rs769659540

H353D

0.37 (IS)

−0.36 (DS)

−0.59 (DS)

−0.83 (DS)

−0.81 (DS)

−0.77 (DS)

rs1177103234

Y357H

−2.05 (DS)

−1.25 (DS)

−1.19 (DS)

−1.26 (DS)

−0.45 (DS)

−1.08 (DS)

  1. SUB Amino acid substitution, Pred Prediction, DS Decrease stability, IS Increase Stability